Cell-Effective Transition-State Analogue of Phenylethanolamine N-Methyltransferase.
Mahmoodi N, Minnow YVT, Harijan RK, Bedard GT, Schramm VL.
Mahmoodi N, et al.
Biochemistry. 2023 Aug 1;62(15):2257-2268. doi: 10.1021/acs.biochem.3c00103. Epub 2023 Jul 19.
Biochemistry. 2023.
PMID: 37467463
Free PMC article.
A synthetic strategy for first-generation TS analogues of human PNMT (hPNMT) permitted structural analysis of hPNMT and revealed potential for second-generation inhibitors [Mahmoodi, N.; J. Am. Chem. Soc. 2020, 142, 14222-14233]. A second-generation TS analogue inhibitor o …
A synthetic strategy for first-generation TS analogues of human PNMT (hPNMT) permitted structural analysis of hPNMT and revealed potential f …